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Free Content Unchanged acetylation of isoniazid by alcohol intake

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Abstract:

SETTING: In 10 healthy subjects, the influence of acute alcohol intake on the pharmacokinetics of isoniazid (INH) was studied.

OBJECTIVE: To test the hypothesis that alcohol increases the conversion of INH by acetylation into its metabolite acetylisoniazid.

DESIGN: In a crossover design, an oral dose of 300 mg INH was administered on 2 separate days, 14 days apart, with or without alcohol to a serum alcohol of about 21 mmol/l (1 g/l) maintained for 12 h.

RESULTS: Neither the metabolism of INH nor that of acetylisoniazid was changed by acute alcohol intake.

CONCLUSION: Acute alcohol intake has no impact on the conversion of INH to its metabolite acetylisoniazid, which is catalysed by the enzyme N-acetyltranferase. Accordingly, a metabolic effect of acute alcohol intake on INH metabolism probably contributes little to the therapeutic failure of anti-tuberculosis treatment among alcoholics.

Keywords: acetylisoniazid; alcohol; isoniazid; metabolism; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Internal Medicine I, Bispebjerg Hospital, Copenhagen, Denmark 2: Clinical Biochemistry, Bispebjerg Hospital, Copenhagen, Denmark 3: Clinical Pharmacology, Bispebjerg Hospital, Copenhagen, Denmark

Publication date: November 1, 2004

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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