Comparison of clinical outcome with oral and inhaled bronchodilators in the management of wheezy children aged 1–59 months in the community: a randomised trial in Pakistan
METHODS: In a randomised multicentre trial, wheezy children aged 1–59 months with fast breathing and/or lower chest indrawing received oral or inhaled salbutamol at home after responding to up to three cycles of inhaled bronchodilators. They were re-assessed on days 3 and 5 for clinical outcome.
RESULTS: From May 2001 to August 2002, 780 children were enrolled; 390 each were randomised to oral and inhaled salbutamol. On day 5, 324 (83.1%) children in the oral and 328 (84.1%) in the inhaled group were completely well. There were no differences in clinical outcome of both modes of therapy.
CONCLUSIONS: The clinical outcome of children aged 1–59 months with wheeze is similar when treated with oral or inhaled salbutamol. Acute respiratory infection control programmes in developing countries should continue to use oral bronchodilators for the management of wheeze to save both time and money.
Document Type: Regular Paper
Affiliations: 1: The Children's Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan 2: Department of Child and Adolescent Health and Development, World Health Organization, Geneva, Switzerland 3: Children's Hospital, Lahore, Punjab, Pakistan 4: Department of Paediatrics, Rawalpindi General Hospital, Rawalpindi, Punjab, Pakistan
Publication date: 01 November 2004
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