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Outcome of tuberculosis retreatment in routine conditions in Cotonou, Benin

Authors: Gninafon, M.1; Tawo, L.1; Kassa, F.1; Monteiro, G. P.1; Zellweger, J-P.2; Shang, H.2; Lambregts, K.3; Trébucq, A.4

Source: The International Journal of Tuberculosis and Lung Disease, Volume 8, Number 10, October 2004 , pp. 1242-1247(6)

Publisher: International Union Against Tuberculosis and Lung Disease

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Abstract:

SETTING: National Tuberculosis Programme (NTP), Cotonou, Benin. OBJECTIVE: To study the patient characteristics and outcome of tuberculosis retreatment cases in a well-functioning NTP. METHODS: A retrospective, register-based study of all smear-positive pulmonary tuberculosis cases put on retreatment (2SERHZ/1ERHZ/5R3H3E3) between 1992 and 2001 in Cotonou. For comparison, information on new smear-positive cases in Cotonou in 1999 was entered and analysed. RESULTS: Of 8103 tuberculosis patients registered, 642 were put on retreatment. The analysis is mainly based on the 236 patients whose initial treatment regimen records were available (113 relapses, 84 failures, 39 returns after default). Most of the relapse (57%) and return after default (72%) cases were put on retreatment within 12 months after stopping their initial treatment. Overall, the retreatment results were satisfactory (78% success) and comparable with those of new cases (82%); the failure rates were low (3%), as were those for initial treatment (1%). There were more defaulters from retreatment among those who had already defaulted from initial treatment (21%). Treatment success rates were better among women than men. CONCLUSION: The standardised retreatment regimen is effective in Cotonou, probably because the NTP is functioning well, there are no drug shortages, drug taking is strictly supervised, and a good treatment plan is followed.

Keywords: Benin; cohort; result; retreatment; tuberculosis

Document Type: Regular Paper

Affiliations: 1: National Tuberculosis Programme, Cotonou, Benin 2: Ligue Pulmonaire Suisse, Berne, Switzerland 3: Royal Netherlands Tuberculosis Association (KNCV), The Hague, The Netherlands 4: International Union Against Tuberculosis and Lung Disease, Paris, France

Publication date: October 1, 2004

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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