Bronchial hyperresponsiveness in two populations with different prevalences of atopy
Abstract:SETTING: Random population samples of young adults from Tartu, Estonia (n = 307) and Uppsala, Sweden (n = 498) in the framework of the European Community Respiratory Health Survey (ECRHS).
OBJECTIVE: To compare the prevalence and risk factors for bronchial hyperresponsiveness (BHR) to methacholine in two centres with similar climate and ethnicity but differences in the prevalence of atopy, asthma and respiratory symptoms.
DESIGN: General population-based cross-sectional survey.
RESULTS: The prevalence of BHR using the cut-off points 1.5, 1.0 and 0.5 mg was 19%, 12% and 8% in Tartu and 11%, 7% and 2%, respectively, in Uppsala. Current smoking was a common risk factor for BHR in both centres. Female sex (odds ratio [OR] 2.9), sensitisation to cat (OR 5.9) and visible mould in the home (OR 2.4) were independent risk factors for BHR in Tartu. In Uppsala, BHR was significantly associated with total IgE levels (OR 2.0) and exposure to environmental tobacco smoke (OR 3.3).
CONCLUSION: The high prevalence of BHR can explain the high prevalence of respiratory symptoms in Tartu and indicates that causes other than asthma and atopy can be responsible for the high prevalence of BHR in a population.
Document Type: Regular Paper
Affiliations: 1: Lung Clinic, Tartu University Clinics, Tartu, Estonia; and Department of Medical Sciences, Respiratory Medicine and Allergology, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden 2: Department of Medical Sciences, Respiratory Medicine and Allergology, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden; and Asthma Research Centre, Uppsala University, Uppsala, Sweden 3: Centre for Allergy Research and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Publication date: 2004-10-01
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