Identification of a familial cluster of pulmonary Mycobacterium bovis disease [Case Study]
DESIGN: Retrospective review of a cluster of three pulmonary Mycobacterium bovis cases occurring in a family, with genotyping of M. bovis strains isolated from the family members.
RESULTS: The genotypes of the M. bovis isolates were identical, as determined by three different methods: IS6110 restriction fragment length polymorphism, spoligoytping and mycobacterial interspersed repetitive units–variable number tandem repeat analyses.
CONCLUSION: The identification of three acid-fast bacilli (AFB) smear-positive pulmonary M. bovis cases, presenting in a single family and caused by an identical strain, suggests that person-to-person transmission of this organism may have occurred, although infection of one or more family members through ingestion of a contaminated dairy product could not be excluded.
Document Type: Short Communication
Affiliations: 1: Tuberculosis Control Program, San Diego County, San Diego, California, USA 2: AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 3: Microbial Diseases Laboratory, California Department of Health Services, Berkeley, California, USA 4: Public Health Laboratory, San Diego County, San Diego, California, USA
Publication date: 2004-09-01
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