Free Content Local production of nitric oxide in patients with tuberculosis

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Nitric oxide (NO), produced by the inducible nitric oxide synthase (iNOS), is important in host defence against Mycobacterium tuberculosis in rodents, but the presence of high-output NO production in human tuberculosis has been controversial. We investigated iNOS and nitrotyrosine (Ntyr) expression in pleural (n = 7), pulmonary (n = 5) and lymph node biopsies (n = 5) from untreated, newly diagnosed tuberculosis patients. Many iNOS and Ntyr reactive macrophages were observed in granulomas, including Langhans giant cells, indicating high-output NO production at the primary site of disease in tuberculosis.

Keywords: granuloma; iNOS; nitric oxide; nitrotyrosine; tuberculosis

Document Type: Short Communication

Affiliations: 1: Division of Medical Microbiology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden 2: Department of Pathology, Karolinska Hospital, Stockholm, Sweden 3: Armauer Hansen Research Institute, Addis Ababa, Ethiopia 4: Department of Experimental Pathology, Instituto de la Nutrición, Mexico City, Mexico 5: Department of Infectious Diseases, Karolinska Institute, Stockholm, Sweden

Publication date: September 1, 2004

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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