Right heart dysfunction in post-tuberculosis emphysema
OBJECTIVE: To evaluate the pump performance of right heart before and after exercise in post-tuberculosis emphysema.
DESIGN: In patients with post-tuberculosis or primary emphysema (similar lung volumes), body plethysmography, arterial blood gas analysis and echocardiography were performed at rest and after exercise. Right heart pump performance was evaluated with the ejection fraction.
RESULTS: At rest, in post-tuberculosis emphysema, diffusing capacity (mean ± SE 72.7 ± 3.9 vs. 91.0 ± 7.1% of reference) and right ventricular ejection fraction (57.5 ± 1.4 vs. 61.3 ± 1.2%) were lower and PaCO2 (42.7 ± 1.1 vs. 38.6 ± 0.7 mmHg) was higher, while lung compliance, airway resistance, PaO2, and alveolar-arterial oxygen difference were not different. After exercise, PaO2 (65.6 ± 2.8 vs. 80.5 ± 3.5 mmHg) and right ventricular ejection fraction (51.2 ± 2.4 vs. 59.6 ± 1.7%) were lower and PaCO2 (47.0 ± 1.5 vs. 40.9 ± 1.5 mmHg) was higher in post-tuberculosis emphysema, whereas alveolar-arterial oxygen difference was not different. PaCO2 and alveolar-arterial oxygen difference increased, and PaO2 and right ventricular ejection fraction decreased in post-tuberculosis emphysema, while they did not significantly change in primary emphysema.
CONCLUSION: In post-tuberculosis emphysema, the impairment of gas exchange was more serious. Global assessment should be focused on right heart dysfunction which might be more affected than in primary emphysema.
Document Type: Regular Paper
Affiliations: 1: Seoul National University Boramae Hospital, Seoul, Republic of Korea; and Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea 2: Seoul National University Boramae Hospital, Seoul, Republic of Korea
Publication date: 2004-09-01
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
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