Candidate genetic polymorphisms for asthma in Chinese schoolchildren from Hong Kong
Source: The International Journal of Tuberculosis and Lung Disease, Volume 8, Number 5, May 2004 , pp. 519-527(9)
Abstract:BACKGROUND: Polymorphisms in several genes have been associated with asthma, atopy and bronchial hyperresponsiveness in white and Japanese populations. In this study we tested for associations of 11 polymorphisms with wheeze and asthma in 10-year-old Chinese schoolchildren.
METHODS: The subjects were 107 children who had wheeze in the last 12 months and 118 without wheeze in the last 12 months. They were randomly selected from 3110 children who took part in Phase II of the International Study of Asthma and Allergies in Childhood. These schoolchildren underwent questionnaire, spirometry and methacholine challenge testing.
RESULTS: The A allele of the tumor necrosis factor-α (TNFA) G-308A polymorphism was significantly associated with wheeze in the last 12 months (odds ratio [OR] 2.1, P = 0.04) and current asthma (OR 2.6, P = 0.006). When stratified by gender, these associations were only seen in the female study participants. In girls, the OR for the TNFA-308A allele and wheeze in the last 12 months was 3.6 (P = 0.01) and for current asthma it was 6.0 (P = 0.0006).
CONCLUSION: The A allele of the TNFA G-308A polymorphism was a risk factor for asthma-related phenotypes in girls but not boys.
Document Type: Regular Paper
Affiliations: 1: Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 2: Department of Paediatrics, Chinese University of Hong Kong, Hong Kong 3: Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; and Department of Medicine, University of Hong Kong, Hong Kong
Publication date: 2004-05-01
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