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Free Content Estimation of annual risk of tuberculosis infection (ARTI) among children aged 1–9 years in the south zone of India

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OBJECTIVE: To estimate the annual risk of tuberculosis infection (ARTI) among children aged 1–9 years in the south zone of India.

SETTING: The survey was carried out in a representative sample of villages and census enumeration blocks of towns in four south Indian states, as a part of a nationwide tuberculin survey.

DESIGN: Six districts were selected through systematic random sampling. Four hundred and twenty rural clusters and 180 urban clusters were selected from these districts on the basis of the rural–urban ratio in the entire zone. To obtain the required sample of 12000 children without bacille Calmette-GuĂ©rin (BCG) vaccination, 51000 had to be covered. Eighty-five children from each cluster were tuberculin tested and read for reaction sizes. The ARTI was computed from the estimated prevalence of TB infection among children without a BCG scar.

RESULT: Among 52951 children registered for the study, 50846 (96%) had a tuberculin test result. The BCG coverage for the study population was about 65%. Among 17811 children without a BCG scar, the prevalence of infection was 5.9% (95%CI 4.0–7.7%); the corresponding ARTI was 1.7% (95%CI 0.7–1.4%).

CONCLUSION: The estimated ARTI for the south zone is 1.0%, as compared to the national average of 1.7% used for programme evaluation. This baseline information should be useful for the assessment of future trends.
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Keywords: annual risk of tuberculosis infection; south India; tuberculosis epidemiology

Document Type: Regular Paper

Affiliations: 1: Tuberculosis Research Centre, ICMR, Chennai, India 2: National Tuberculosis Institute, Bangalore, India 3: NSS-ARI Project, Chennai, India

Publication date: 2004-04-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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