Etiology of pulmonary infections in predominantly HIV-infected adults with suspected tuberculosis, Botswana
Authors: Lockman S.1; Hone N.2; Kenyon T.A.3; Mwasekaga M.4; Villauthapillai M.5; Creek T.6; Zell E.7; Kirby A.7; Thacker W.L.7; Talkington D.7; Moura I.N.8; Binkin N.J.9; Clay L.3; Tappero J.W.10
Source: The International Journal of Tuberculosis and Lung Disease, Volume 7, Number 8, August 2003 , pp. 714-723(10)
Publisher: International Union Against Tuberculosis and Lung Disease
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Abstract:
SETTING: In countries with high HIV rates, diagnosis of lower respiratory disease etiology is both challenging and clinically important.OBJECTIVE: To determine the etiology of lower respiratory tract disease among persons with suspected tuberculosis (TB) and abnormal chest X-rays in a setting with very high HIV seroprevalence.DESIGN: Cross-sectional prevalence data from a prospective cohort of predominantly hospitalized adults with suspected TB in Botswana, January–December 1997.RESULTS: Of 229 patients, 86% were HIV-positive and 71% had a pathogen identified. TB was confirmed in 52%, 17% had acute mycoplasma pneumonia, 3% had Pneumocystis carinii, 27% grew a bacterial pathogen from sputum and 8% from blood. Ninety-four per cent of TB diagnoses were made through expectorated sputum and only 5% of TB cases were diagnosed by sputum induction alone. Polymerase chain reaction (PCR) for Mycobacterium tuberculosis had positive and negative predictive values of 94% and 59%, respectively. Male sex, cough <2 weeks, and tuberculin skin test
5 mm were independently associated with culture-positive TB among persons with negative acid-fast bacilli smears. Co-infection with two or more pathogens occurred in 25%.CONCLUSIONS: Mycoplasma pneumoniae infection was quite common despite clinical suspicion of TB, and sputum induction and PCR did not significantly improve our ability to diagnose TB, although clinical presentation had some predictive value.
Keywords: respiratory disease diagnosis; smear-negative tuberculosis; HIV; Botswana, Africa; Mycoplasma pneumoniae
Document Type: Regular paper
Affiliations: 1: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA; Centers for Disease Control and Prevention BOTUSA TB Project, Gaborone, Botswana; and the Epidemic Intelligence Service, Centers for Di 10: Centers for Disease Control and Prevention BOTUSA TB Project, Gaborone, Botswana; NCHSTP, DTBE, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; and NCHSTP, HIV, Centers for Disease Control and Prevention, Bangkok, Thailand 2: Department of Medicine, Nyangabgwe Hospital, Francistown, Botswana 3: Centers for Disease Control and Prevention BOTUSA TB Project, Gaborone, Botswana 4: National TB Reference Laboratory, Gaborone, Botswana 5: Microbiology Section, National Health Laboratory, Gaborone, Botswana 6: Centers for Disease Control and Prevention BOTUSA TB Project, Gaborone, Botswana; and the Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 7: Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 8: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 9: NCHSTP, DTBE, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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