Authors: McLaughlin S.I.¹; Spradling P.²; Drociuk D.³; Ridzon R.⁴; Pozsik C.J.³; Onorato I.⁵

Source: The International Journal of Tuberculosis and Lung Disease, Volume 7, Number 7, July 2003 , pp. 665-672(8)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

BACKGROUND: In August 1999, a prison inmate in-fected with the human immunodeficiency virus (HIV) was diagnosed with pulmonary tuberculosis (TB). This source patient lived in a prison dormitory housing over 300 HIV-infected men, and was symptomatic for at least 2 months prior to diagnosis. We report a large outbreak of TB in HIV-infected prison inmates with subsequent transmission of Mycobacterium tuberculosis outside the prison.

METHODS: Exposed inmates were screened by symptom review, chest radiograph and tuberculin skin test (TST) in September and December 1999. We recorded CD4 cell counts, viral loads and receipt of highly active antiretroviral therapy (HAART).

RESULTS: The source patient lived on the right side of a two-sided dormitory exclusively housing HIV-infected men. Of 114 men tested from the right side, 75 (66%) had documented TST conversions. Of 96 converters overall, 82 (85%) had TSTs measuring 15 mm. Within 6 months of diagnosis of TB in the source patient, 30 additional inmates and a healthcare worker who cared for the source patient developed TB disease. Two other inmates developed TB disease in spring of 2001.

CONCLUSIONS: We describe extensive transmission of M. tuberculosis in a group of HIV-infected prison inmates with high TST conversion rates and subsequent transmission in the community. In settings where HIV-infected persons are congregated, the consequences of TB outbreaks are magnified.

Keywords: tuberculosis; outbreak; HIV; prison; congregation

Document Type: Regular paper

Affiliations: 1: National Immunization Program, Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: National Center for HIV, STD and TB Prevention, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 3: Department of TB Control, South Carolina Department of Health and Environmental Control, Columbia, South Carolina, USA 4: HIV, TB and Reproductive Health, Bill and Melinda Gates Foundation, Seattle, Washington, USA 5: National Center for HIV, STD and TB Prevention, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Publication date: 2003-07-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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