Clonal relationships in a shelter-associated outbreak of drug-resistant tuberculosis: 1983–1997
DESIGN: Isolates from 10 HS-resistant patients—four non-viable isolates from the 1980s and six viable isolates from 1996–1997—were sent to the Centers for Disease Control and Prevention for M-L PCR fingerprinting. These results were combined with record reviews of older cases and an ongoing epidemiologic investigation.
RESULTS: Eight of 10 of the isolates were clonal, and the other two were strongly suspected matches. Epidemiologic investigation determined that transmission continued to occur after the initial outbreak in 1984–1985, and that a streptomycin-monoresistant variant of the strain was also circulating.
CONCLUSION: M-L PCR fingerprinting combined with epidemiology was able to document links between cases across 15 years.
Document Type: Regular Paper
Affiliations: 1: Massachusetts Department of Public Health, Division of TB Prevention and Control, Jamaica Plain, Massachusetts, USA 2: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 3: Boston Public Health Commission TB Division, Boston, Massachusetts, USA 4: Massachusetts Department of Public Health, Division of TB Prevention and Control, Jamaica Plain, Massachusetts, and Boston Public Health Commission TB Division, Boston, Massachusetts, USA 5: New York State Department of Health, Albany, New York, USA 6: Massachusetts Department of Public Health, Division of TB Prevention and Control, Jamaica Plain, Massachusetts, and Harvard Medical School, Cambridge Hospital, Cambridge, Massachusetts, USA
Publication date: 2002-10-01
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