@article {Burman:September 2002:1027-3719:839, author = "Burman W. J.", author = "Terra M.", author = "Breese P.", author = "Cohn D.", author = "Reves R.", title = "Lack of toxicity from concomitant directly observed disulfiram and isoniazid-containing therapy for active tuberculosis", journal = "The International Journal of Tuberculosis and Lung Disease", volume = "6", year = "September 2002", abstract = "

We retrospectively evaluated the use of disulfiram among alcoholic patients being treated for active tuberculosis. There were 13 alcoholics treated with disulfiram, 105 alcoholics not on disulfiram, and 249 non-alcoholics. Rates of toxicity were higher among alcoholics than among non-alcoholics (58% vs. 32%), but there was no difference between alcoholics taking and those not taking disulfiram (61% vs. 57%). There were no neurological side effects in the disulfiram group. Disulfiram appeared to be safe when added to intermittent, directly observed isoniazid-containing tuberculosis treatment, and was useful in managing complications of alcohol abuse. However, the small number of patients on disulfiram limits the strength of this negative finding.

", pages = "839-842(4)", url = "http://www.ingentaconnect.com/content/iuatld/ijtld/2002/00000006/00000009/art00015" }