5′ dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas
Abstract:SETTING: Houston Tuberculosis Initiative (HTI) and Baylor College of Medicine, Houston, Texas.
OBJECTIVE: To further explore the association between the polymorphisms of NRAMP1 and human susceptibility/resistance to tuberculosis (TB), specifically to determine whether the reported association shown for blacks and Asians holds true for Caucasian populations.
DESIGN: In a case-control study, 135 adult Caucasian TB patients and 108 adult Caucasian HIV-seronegative non-TB controls were analyzed for the association between the polymorphisms in NRAMP1 gene and clinical TB.
RESULTS: Heterozygote at 5′(GT)n, a dinucleotide repeat polymorphism in the promoter of NRAMP1, was observed at significantly higher frequencies among HIV-negative patients with pulmonary TB (41.6%; OR 2.02; 95%CI 1.11–3.64), extra-pulmonary TB (66.7%; OR 4.80; 95%CI 1.34–17.15), and HIV-seropositive TB patients (50%; OR 3.77; 95%CI 1.33–10.66) in comparison with the controls (27.8%). Homozygotes (GT)10,10 were over-represented among HIV-positive TB patients (18.2%; OR 6.86; 95%CI 1.55–30.21) compared to the controls (5.5%).
CONCLUSION: These findings suggest that the 5′(GT)n polymorphism of NRAMP1 modifies TB susceptibility in this Caucasian population, and could possibly be related to the site of infection among HIV-negative individuals and HIV-coinfected TB.
Document Type: Regular Paper
Affiliations: 1: Department of Pathology, Baylor College of Medicine, Houston, Texas, USA 2: Departments of Pathology and Medicine, Baylor College of Medicine, Houston, Texas, USA 3: Department of Medicine, Baylor College of Medicine, Houston, Texas, USA 4: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Publication date: September 1, 2002
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