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Free Content 5′ dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas

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Abstract:

SETTING: Houston Tuberculosis Initiative (HTI) and Baylor College of Medicine, Houston, Texas.

OBJECTIVE: To further explore the association between the polymorphisms of NRAMP1 and human susceptibility/resistance to tuberculosis (TB), specifically to determine whether the reported association shown for blacks and Asians holds true for Caucasian populations.

DESIGN: In a case-control study, 135 adult Caucasian TB patients and 108 adult Caucasian HIV-seronegative non-TB controls were analyzed for the association between the polymorphisms in NRAMP1 gene and clinical TB.

RESULTS: Heterozygote at 5′(GT)n, a dinucleotide repeat polymorphism in the promoter of NRAMP1, was observed at significantly higher frequencies among HIV-negative patients with pulmonary TB (41.6%; OR 2.02; 95%CI 1.11–3.64), extra-pulmonary TB (66.7%; OR 4.80; 95%CI 1.34–17.15), and HIV-seropositive TB patients (50%; OR 3.77; 95%CI 1.33–10.66) in comparison with the controls (27.8%). Homozygotes (GT)10,10 were over-represented among HIV-positive TB patients (18.2%; OR 6.86; 95%CI 1.55–30.21) compared to the controls (5.5%).

CONCLUSION: These findings suggest that the 5′(GT)n polymorphism of NRAMP1 modifies TB susceptibility in this Caucasian population, and could possibly be related to the site of infection among HIV-negative individuals and HIV-coinfected TB.

Keywords: NRAMP1; polymorphism; susceptibility; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Department of Pathology, Baylor College of Medicine, Houston, Texas, USA 2: Departments of Pathology and Medicine, Baylor College of Medicine, Houston, Texas, USA 3: Department of Medicine, Baylor College of Medicine, Houston, Texas, USA 4: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Publication date: September 1, 2002

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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