If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Free Content Tuberculosis treatment outcome monitoring: Blackburn 1988–2000

 Download
(PDF 54.6kb)
 
Download Article:

Abstract:

SETTING: All cases of tuberculosis in a high prevalence district (population 269000) of England.

OBJECTIVE: To analyse the tuberculosis programme outcome for confirmed pulmonary tuberculosis, and all other categories of cases for 1988–2000 inclusive.

DESIGN: The outcome of all cases treated during the period 1988–2000 inclusive was assessed by agreed European outcome criteria, retrospectively for 1988–1998 and prospectively for 1999–2000.

RESULTS: A total of 729 tuberculosis cases were notified, with 209 definite (culture-positive) pulmonary cases. Of the 205 definite pulmonary cases treated in life, 182 received self-administered treatment (SAT) and 23 directly observed treatment (DOT), with an 88% cure/completion rate and a 12% death rate. The relapse rate for SAT was 1/182 (0.5%) and 1/23 for DOT (4.3%). The cure/completion rate for all patients together was 94.3%, with a relapse rate of 0.8%.

CONCLUSION: In this resource-rich setting, treatment largely by SAT, but carefully monitored, gives a very high cure/completion rate. Universal rather than selective DOT would make little additional impact on patient outcome. These outcomes are not likely to be reproduceable, however, with SAT in a resource-poor setting.

Keywords: DOT; United Kingdom; outcome; treatment; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Chest Clinic, Blackburn Royal Infirmary, Blackburn, UK; and Lancashire Postgraduate School of Medicine and Health, University of Central Lancashire, Preston, Lancashire, UK 2: Chest Clinic, Blackburn Royal Infirmary, Blackburn, Lancashire, UK

Publication date: August 1, 2002

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • ingentaconnect is not responsible for the content or availability of external websites
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more