Implementation of the DOTS strategy for tuberculosis in the Leningrad Region, Russian Federation (1998–1999)
Abstract:SETTING: The DOTS pilot project for tuberculosis control in the Leningrad Region of the Russian Federation, supported by the Finnish Lung Health Association and the World Health Organization (WHO).
OBJECTIVE: To assess the efficacy of WHO-recommended standard short-course chemotherapy in newly detected pulmonary tuberculosis cases positive by smear or with extensive lung lesions suggestive of culture positivity, under project conditions.
METHODS: Analysis of data on case detection, sputum smear conversion and treatment outcome based on standardised (WHO) registers from districts and a central computerised database.
RESULTS: Of 859 adult pulmonary tuberculosis cases (292 smear-positive) notified in the Leningrad Region in the study period, 312 new cases were included in the project. The sputum conversion rate at the end of the second month was 82.8% and 91.1% at the end of the third month. Of bacteriologically confirmed cases, 71.3% were successfully treated, 4.9% died, 11.7% defaulted and 8.1% failed.
CONCLUSION: In the first year of the pilot project in the Leningrad Region, the DOTS strategy revealed feasibility and moderate efficacy among new pulmonary tuberculosis cases who were either smear-positive or showed extensive lung lesions on chest X-ray, and who were therefore of high epidemiological and medical priority.
Document Type: Regular Paper
Affiliations: 1: Finnish Lung Health Association, Helsinki, Finland 2: Regional TB Centre of Leningrad Region, Saint-Petersburg, Russian Federation 3: National TB Surveillance Unit, Department of Chest Diseases, University Hospital, Prague, Czech Republic 4: Regional Health Committee of the Leningrad Region, Government of Leningrad Region, Saint-Petersburg, Russian Federation
Publication date: March 1, 2002
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