Skip to main content

Free Content Skin test reactions to Mycobacterium tuberculosis purified protein derivative and Mycobacterium avium sensitin among health care workers and medical students in the United States

Download Article:
(PDF 164.865234375 kb)
SETTING: Health care workers and medical students in the United States subject to annual tuberculin skin testing.

OBJECTIVE: To use skin testing with Mycobacterium avium sensitin (MAS) to determine contemporary rates of infection with non-tuberculous mycobacteria (NTM) and their effect on reactions to M. tuberculosis purified protein derivative (PPD).

DESIGN: Dual skin testing was performed with PPD and MAS on 784 health care workers and medical students in the northern and southern US. MAS reactions that were ≥5 mm and also ≥3 mm larger than the PPD reaction were defined as MAS dominant and due to NTM.

RESULTS: MAS reactions were ≥5 mm in 40% and ≥15 mm in 18% of subjects; 95% were MAS dominant. MAS dominant reactions were more common in the south than the north (P < 0.001). PPD reactions were ≥15 mm in 3% of subjects. PPD reactions ≥15 mm were more common among males, foreign born subjects and subjects with BCG immunization (all P < 0.001). MAS dominant reactions were found in 82% of subjects with 5–9 mm PPD reactions and 50% with 10–14 mm PPD reactions; these reactions were more common among whites (P = 0.046), US-born (P = 0.038) and subjects without BCG immunization (P = 0.004).

CONCLUSIONS: Infections with NTM are responsible for the majority of 5–14 mm PPD reactions among US-born health care workers and medical students subject to annual tuberculin testing.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Mycobacterium avium; purified protein derivative; skin testing; tuberculin; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Infectious Disease Section and Clinical Research Section, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA 2: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine and Grady Memorial Hospital, Atlanta, Georgia, USA 3: University of North Carolina Hospitals, Chapel Hill, North Carolina, USA 4: University of Texas Health Center, Tyler, Texas, USA

Publication date: 2001-12-01

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more