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Free Content Quantitative bacillary response to treatment in Mycobacterium tuberculosis infected and M. africanum infected adults with pulmonary tuberculosis

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Data regarding possible differences in microbiological response to therapy of disease caused by Mycobacterium tuberculosis and M. africanum are limited. Presenting clinical characteristics and sputum bacillary load during standard short-course chemotherapy in patients with newly-diagnosed pulmonary tuberculosis due to M. tuberculosis (n = 7) and M. africanum (n = 6) were compared. Changes in sputum bacillary load were measured using quantitative acid-fast bacilli smears, colony forming unit assay, and time until positive culture in the BACTEC® radiometric system. Presentation and response to short course chemotherapy were comparable between patients infected with M. tuberculosis and those infected with M. africanum.
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Keywords: M. africanum; Mycobacterium tuberculosis; chemotherapy; colony forming units; radiometric; tuberculosis

Document Type: Short Communication

Affiliations: 1: Department of Medical Microbiology, Makerere University; and Joint Clinical Research Centre, Kampala, Uganda 2: Department of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine; and University Hospitals of Cleveland, Cleveland, Ohio, USA 3: Department of Medicine, Makerere University, Kampala, Uganda 4: University Hospitals of Cleveland, Cleveland, Ohio, USA 5: Joint Clinical Research Centre, Kampala, Uganda 6: National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany 7: University of Medicine and Dentistry, Newark, New Jersey, USA 8: University of Arkansas for Medical Sciences, John L. McClellan Memorial Veterans Hospital, Little Rock, Arkansas, USA

Publication date: 2001-06-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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