Quantitative bacillary response to treatment in Mycobacterium tuberculosis infected and M. africanum infected adults with pulmonary tuberculosis
Abstract:Data regarding possible differences in microbiological response to therapy of disease caused by Mycobacterium tuberculosis and M. africanum are limited. Presenting clinical characteristics and sputum bacillary load during standard short-course chemotherapy in patients with newly-diagnosed pulmonary tuberculosis due to M. tuberculosis (n = 7) and M. africanum (n = 6) were compared. Changes in sputum bacillary load were measured using quantitative acid-fast bacilli smears, colony forming unit assay, and time until positive culture in the BACTEC® radiometric system. Presentation and response to short course chemotherapy were comparable between patients infected with M. tuberculosis and those infected with M. africanum.
Document Type: Short Communication
Affiliations: 1: Department of Medical Microbiology, Makerere University; and Joint Clinical Research Centre, Kampala, Uganda 2: Department of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine; and University Hospitals of Cleveland, Cleveland, Ohio, USA 3: Department of Medicine, Makerere University, Kampala, Uganda 4: University Hospitals of Cleveland, Cleveland, Ohio, USA 5: Joint Clinical Research Centre, Kampala, Uganda 6: National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany 7: University of Medicine and Dentistry, Newark, New Jersey, USA 8: University of Arkansas for Medical Sciences, John L. McClellan Memorial Veterans Hospital, Little Rock, Arkansas, USA
Publication date: June 1, 2001
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