Increased resistance to ciprofloxacin and ofloxacin in multidrug-resistant Mycobacterium tuberculosis isolates from patients seen at a tertiary hospital in the Philippines
Authors: Grimaldo E. R.1; Tupasi T. E.1; Rivera A. B.1; Quelapio Ma. I. D.1; Cardaño R. C.1; Derilo J. O.1; Belen V. A.1
Source: The International Journal of Tuberculosis and Lung Disease, Volume 5, Number 6, June 2001 , pp. 546-550(5)
Publisher: International Union Against Tuberculosis and Lung Disease
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Abstract:
SETTING: A hospital-based study at the Makati Medical Center, Makati City, Philippines, a hyperendemic area for tuberculosis (TB).
OBJECTIVE: To determine the susceptibility of Mycobacterium tuberculosis to ciprofloxacin and ofloxacin.
DESIGN: Retrospective analysis of drug susceptibility tests (DST) of M. tuberculosis isolated from 1995–2000.
RESULTS: Resistance to ciprofloxacin was 26.8%, ofloxacin 35.3%, and multidrug resistance (MDR) was 17.2%. Of the MDR strains, 51.4% were resistant to ciprofloxacin and ofloxacin. Acquired resistance was significantly higher for all first-line drugs and for ciprofloxacin, but not for ofloxacin. A significant increase in resistance to ciprofloxacin and ofloxacin was noted compared to 1989–1994, while resistance to the first-line drugs was not significantly different.
CONCLUSION: Ciprofloxacin and ofloxacin are now a significantly less effective alternative therapy in tuberculosis, particularly MDR-TB, due to a selection pressure from their widespread use in the treatment of TB and possibly other infections in the community, which is hyperendemic for tuberculosis.
Keywords: MDR-TB; ciprofloxacin; ofloxacin; Philippines
Language: English
Document Type: Regular paper
Affiliations: 1: Tropical Disease Foundation, Makati Medical Center, Legaspi Village, Makati City, Philippines
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