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Free Content Risk factors for nosocomial transmission of multidrug-resistant tuberculosis due to Mycobacterium bovis among HIV-infected patients

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OBJECTIVE: To identify risk factors for transmission of multidrug-resistant tuberculosis (MDR-TB) among hospitalized human immunodeficiency virus (HIV) infected patients exposed during a nosocomial outbreak.

DESIGN: Case control study. Cases were HIV-infected patients with MDR-TB due to Mycobacterium bovis (MDR-TBMb) who acquired the disease after exposure to an MDR-TBMb patient in an hospital ward. Controls were HIV-infected patients exposed to a case of MDR-TBMb in an hospital ward but who did not develop MDR-TBMb during the follow-up.

RESULTS: Nineteen cases and 31 controls were included. CD4 cell counts were significantly lower among cases. Exposure in the infectious diseases ward or exposure to the index patient were associated with development of MDR-TBMb, while exposure during a single-room hospital stay and exposure in the respiratory isolation ward were associated with non-development of MDR-TBMb. A multiple regression logistic model showed that only a CD4 cell count below 50/μL and exposure to the index patient increased the risk of developing MDR-TBMb (P < 0.05). Hospitalization in a single room seemed to protect HIV-infected patients from developing nosocomial MDR-TBMb (P = 0.052).

CONCLUSIONS: Over classic risk factors, such as length of exposure or sharing a room with a case, severe immunosuppression independently increases the risk of MDR-TB transmission in the context of a nosocomial MDR-TB outbreak among HIV-infected patients. This information must be considered in the management of tuberculosis outbreaks. Patients with CD4 cell counts below 50/μL should be the principal group targeted for prevention strategies in nosocomial outbreaks.
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Keywords: CD4 cell count; Mycobacterium bovis; case control study; multidrug-resistant tuberculosis; nosocomial infections; risk factors

Document Type: Regular Paper

Affiliations: 1: Department of Infectious Diseases, Ramón y Cajal Hospital, University of Alcalá, Madrid 2: Department of Preventive Medicine, Ramón y Cajal Hospital, University of Alcalá, Madrid; Department of Preventive Medicine, Clínica Puerta de Hierro, Madrid 3: Department of Microbiology, Ramón y Cajal Hospital, University of Alcalá, Madrid 4: Department of Infectious Diseases, Ramón y Cajal Hospital, University of Alcalá, Madrid and Department of Microbiology, Hospital Juan Canalejo, Coruña, Spain

Publication date: 2001-05-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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