Intrapulmonary pharmacokinetics of ofloxacin in drug-resistant tuberculosis
Abstract:OBJECTIVE: To determine the lung epithelial lining fluid (ELF) and serum levels of ofloxacin in drug-resistant tuberculosis patients during treatment.
DESIGN: Ten drug-resistant tuberculosis patients treated with ofloxacin containing regimens for at least 2 weeks were enrolled in the study. Subjects ingested ofloxacin 10 mg/kg and other anti-tuberculosis agents after overnight fasting.
RESULTS: Serum and bronchoalveolar lavage fluid were collected at 4 hours after treatment and assayed by high performance liquid chromatography. The mean concentrations of ofloxacin in serum and ELF were 5.889 ± 1.096 and 16.583 ± 8.697 mg/L, respectively. The mean ratio of ELF-to-serum ofloxacin concentration was 2.825 ± 1.275.
CONCLUSION: Ofloxacin can penetrate well into the intra-alveolar fluid of patients treated for drug-resistant tuberculosis. The lung ELF concentrations were consistently higher than the minimal inhibitory concentrations of Mycobacterium tuberculosis as determined in vitro.
Document Type: Regular Paper
Affiliations: 1: Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand 2: Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
Publication date: 2001-03-01
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