Molecular determinants of drug resistance in tuberculosis
Authors: P.F. Riska1; W.R. Jacobs Jr.2; D. Alland3
Source: The International Journal of Tuberculosis and Lung Disease, Volume 4, Supplement 1, February 2000 , pp. S4-S10(1)
Publisher: International Union Against Tuberculosis and Lung Disease
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Abstract:
Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-based assays for the identification of drug-resistant TB. This review summarizes the recent discoveries concerning resistance to isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, amikacin, kanamycin and the quinolones.Document Type: Regular paper
Affiliations: 1: State University of New York–Health Science Center at Brooklyn, Brooklyn, New York, New York, USA 2: Howard Hughes Medical Institute at the Albert Einstein College of Medicine, Bronx, New York, New York, USA 3: Montefiore Medical Center, Bronx, New York, New York, USA
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Click here for Page Help