Numbers of IFN-γ-producing cells against ESAT-6 increase in tuberculosis patients during chemotherapy [Technical Note]
Abstract:ESAT-6 is a specific Mycobacterium tuberculosis complex antigen and strong inducer of interferon-gamma (IFN-γ) production by T cells from tuberculosis patient T-cells. We studied the frequency of IFN-γ producing cells reacting to ESAT-6 during anti-tuberculosis chemotherapy. The numbers of IFN-γ producing cells in the peripheral blood were higher in tuberculosis patients after discharge from specific anti-tuberculosis chemotherapy, compared with untreated patients. These results indicate that monitoring specific M. tuberculosis antigen reactivity during anti-tuberculosis chemotherapy may avoid premature termination of treatment and resistant strains.
Document Type: Short Communication
Affiliations: Max-Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
Publication date: December 1, 2000
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