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Free Content Evaluation of a new serodiagnostic tuberculosis test based on immunoglobulin A detection against Kp-90 antigen [Technical Note]

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We evaluated a new serological test for tuberculosis (TB) diagnosis, an enzyme-linked immunosorbent assay which detects the presence of immunoglobulin A (IgA) antibodies in human serum, the Kreatech TB IgA EIA test. The study was performed using 166 serum samples collected in the city of Barcelona, Spain. Fifty-six serum samples were from TB patients and 111 from controls, 40 of which were non-TB pneumonia patients. The test sensitivity was 70.58% in the adult group with pulmonary TB and 50% in the group with extra-pulmonary TB. These sensitivities were similar to those previously reported by others. However, we found that the test had a low specificity of only 68.68%, while specificities of 90% and 95% have been reported. This discrepancy may be attributable to differences in the respective study populations. In our control group we included 40 non-TB pneumonia patients (36% of the entire control group), in whom test specificity dropped to 47.22%. In those studies in which specificities of 90% and above were achieved, very few serum samples from non-TB pneumonia patients were tested (6–12% of the entire control group).
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Keywords: IgA; Kp 90 antigen; enzyme-linked immunosorbent assay; tuberculosis

Document Type: Short Communication

Affiliations: 1: Department of Genetics and Microbiology, Sciences Faculty, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain 2: Microbiology Service, “Germans Trias i Pujol” University Hospital, Badalona, Barcelona, Spain 3: Tuberculosis Prevention and Control Programme, Department of Health and Social Security, Barcelona, Spain

Publication date: 01 November 2000

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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