IngentaConnect Multidrug-resistant tuberculosis: long-term treatment outcome in ...

Authors: W.A. Geerligs¹; R. van Altena¹; W.C.M. de Lange²; D. van Soolingen³; T.S. van der Werf⁴

Source: The International Journal of Tuberculosis and Lung Disease, Volume 4, Number 8, August 2000 , pp. 758-764(7)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: Tuberculosis units (Beatrixoord, Haren; and Dekkerswald, Groesbeek) in the Netherlands.

OBJECTIVE: To study the long-term treatment outcome of patients with multidrug-resistant tuberculosis (MDR-TB).

DESIGN: Descriptive analysis of all consecutively admitted patients with MDR-TB between 1 January 1985 and 1 September 1998, with follow-up until 1 August 1999.

RESULTS: Of 44 patients (31 male) enrolled in the study, 33 were foreign born and none were human immunodeficiency virus positive. At diagnosis 38 patients had sputum-smear positive pulmonary TB, and converted culture negative after a mean of 6 weeks, while six converted to negative later (mean 69 weeks). Most patients had micro-organisms resistant to several antimycobacterial drugs (mean = median: 5), including resistance to isoniazid and rifampin. In-patient treatment lasted a mean of 164 days (range 31–481), and patients were treated with six drugs on average. Side effects were common. Treatment lasted for a mean of 608 days (range 268–1626); five patients are still on treatment. Four patients were operated for TB, and two others were operated for post-TB sequelae. During the follow-up period six patients died, of whom three had active TB; 33 (75%) were considered cured.

CONCLUSION: Mortality was only 14% after a mean follow-up period of 53 months. MDR-TB can be successfully treated, but requires much effort from both patients and carers, and the costs may be higher than is affordable in resource-poor countries.

Keywords: multidrug-resistant tuberculosis; tertiary care centre; outcome; survival

Document Type: Regular paper

Affiliations: 1: Tuberculosis Units of Beatrixoord and Haren, Groesbeek, the Netherlands 2: Tuberculosis Unit of Dekkerswald, Groesbeek, the Netherlands 3: National Reference Laboratory for Tuberculosis, National Institute of Public Health and the Environment, Bilthoven, the Netherlands 4: Intensive and Respiratory Care Unit, Department of Internal Medicine, Groningen University Hospital, Groningen, the Netherlands

Multidrug-resistant tuberculosis: long-term treatment outcome in the Netherlands