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The evaluation of rifampicin bioavailabilities of fixed-dose combinations of anti-tuberculosis drugs: procedures for ensuring laboratory proficiency

Author: Ellard, G. A.

Source: The International Journal of Tuberculosis and Lung Disease, Volume 3, Supplement 3, November 1999 , pp. S322-S324(3)

Publisher: International Union Against Tuberculosis and Lung Disease

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SETTING: The perceived need to demonstrate whether or not the rifampicin bioavailability of commercially manufactured fixed-dose combinations is satisfactory.

OBJECTIVE: To establish an international laboratory network to assess rifampicin bioavailability.

DESIGN: Convenient assay kits were devised to evaluate the ability of laboratories in China, India, Italy, South Africa, Thailand and the USA to determine plasma and urinary concentrations of rifampicin and desacetyl-rifampicin.

RESULTS: Five laboratories, all of whom used high pressure liquid chromatographic methods, were shown to be able to accurately and precisely determine the two compounds.

CONCLUSION: Such a procedure is simple, convenient and objective and could be further employed to enlarge the intended international laboratory network.

Keywords: analytical performance; bioavailability; rifampicin

Document Type: Regular Paper

Affiliations: Department of Medical Microbiology, St. George's Hospital Medical School, London, UK

Publication date: November 1, 1999

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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