Tolerability of twice-weekly rifabutin-isoniazid combinations versus daily isoniazid for latent tuberculosis in HIV-infected subjects: a pilot study
Abstract:The tolerability of and adherence to intermittent short-term rifabutin–isoniazid preventive treatment was assessed in subjects dually infected with Mycobacterium tuberculosis and the human immunodeficiency virus (HIV). In a randomised, open-label, phase II pilot study, 44 subjects received either rifabutin 300 mg and isoniazid 750 mg twice weekly for 3 months (group A, n = 16) or the same regimen with rifabutin at 600 mg (group B, n = 14), or isoniazid 300 mg/day for 6 months (group C, n = 14). Three, two and four subjects in groups A, B, and C, respectively, did not complete their treatment (one case of flu-like syndrome in group B; one methadone withdrawal syndrome in group A; and patient decision in two cases in group A and four in group C). Overall, adverse events were reported by four, nine, and seven subjects in groups A, B and C, respectively. Intermittent combined rifabutin + isoniazid for 3 months had lower default rates than daily standard isoniazid for 6 months. The regimen with rifabutin at 300 mg dose compared favourably to standard isoniazid, and warrants larger efficacy studies to assess its role for the prevention of latent tuberculosis in HIV-infected subjects.
Document Type: Short Communication
Affiliations: 1: Clinic of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy 2: UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland 3: Division of Infectious Diseases, Spedali Civili, Brescia, Italy 4: Division of Infectious Diseases, Poma Hospital, Mantova, Italy 5: Division of Infectious Diseases, Reggio Emilia, Italy
Publication date: November 1, 1999
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