Primary resistance to antituberculosis drugs: a national survey conducted in Côte d'Ivoire in 1995–1996
Abstract:SETTING: A national survey of resistance to the antituberculosis drugs used in Côte d'Ivoire was conducted in 1995–1996.
OBJECTIVE: To determine the rate of primary resistance to antituberculosis drugs.
METHODS: Consecutive new tuberculous patients with positive smear were recruited from tuberculosis centres and rural health centres. Drug susceptibility testing was performed according to the proportion method. Positive cultures were tested against streptomycin, isoniazid, rifampicin, and ethambutol. All resistant strains and 10% of all randomly sampled cultures were sent to an external laboratory for quality control. Human immunodeficiency virus (HIV) tests were performed for consenting patients at the tuberculosis centres.
RESULTS: Among the 430 samples, 320 were available for analysis. Primary resistance to antituberculosis drugs was observed for 13.4% of the patients (43/320); multidrug resistance (to at least isoniazid and rifampicin) was observed for 5.3% of the patients; 14.2% of HIV-negative and 16.2% of HIV-positive patients were resistant to at least one antituberculosis drug (P = 0.70).
CONCLUSION: This study is representative of antituberculosis drug resistance in Côte d'Ivoire. The rate of primary resistance is high and emphasises the need for a sentinel survey of tuberculous resistance. The National Tuberculosis Control Programme needs to make improvements in its management of tuberculosis cases.
Document Type: Regular Paper
Affiliations: 1: Laboratoire de Bacteriologie, Institut Pasteur de Côte d'Ivoire, Paris, France 2: CeDReS, CHU de Treichville, Paris, France 3: Institut de Recherche pour le Développement, ORSTOM Petit Bassam, Paris, France 4: Programme National de Lutte contre le SIDA, les MST et la Tuberculose, Paris, France 5: Institut Pasteur, Centre National de Reference des Mycobacteries, Paris, France
Publication date: September 1, 1999
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