Addressing multidrug-resistant tuberculosis in penitentiary hospitals and in the general population of the former Soviet Union
There are no coherent guidelines for TB control programmes confronted by high pre-existing levels of MDR-TB but who have only limited laboratory, clinical, pharmaceutical and financial resources. A ‘DOTS plus’ strategy has been advocated in which an established TB control programme is complemented by facilities to treat MDR-TB patients. However, the exact format of these programmes remains unresolved. Further research is required to describe the natural history of MDR-TB infection, to determine the failure rate of (and the additional resistance induced by) standard short-course treatment when MDR-TB is prevalent, to decide whether standardised or individualised second-line regimens can be employed, and to define the laboratory facilities required by a ‘DOTS plus’ programme.
Document Type: Review Article
Affiliations: Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium
Publication date: 1999-07-01
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