Phase II trial of recombinant interferon-α2b in patients with advanced intractable multidrug-resistant pulmonary tuberculosis: long-term follow-up
Abstract:SETTING: Multidrug-resistant tuberculosis patients without human immunodeficiency virus (HIV) infection, with Mycobacterium tuberculosis resistant to almost all of the available drugs.
OBJECTIVE: Limited phase II trial with recombinant interferon-α2b in five chronic multidrug-resistant tuberculosis patients.
METHODS: Three million units of r-IFN-α2b were administered subcutaneously every week for 12 weeks. Before and after treatment, and during a 30-month follow-up period, the patients underwent clinical and radiological examination, together with bacteriological, immunological and routine laboratory testing.
RESULTS: Two of the five patients became long-term sputum smear and culture negative after r-IFN-α2b therapy; one of the patients showed clinical improvement and negative smear after therapy, but remained culture positive. The other two patients showed no response.
CONCLUSION: The results of this trial suggest that r-IFN-α2b should be evaluated further in multidrug-resistant tuberculosis in prospective controlled trials.
Document Type: Regular Paper
Affiliations: 1: Institute of Pulmonary Diseases, University of Buenos Aires, Argentina 2: Immunology Department, University Del Salvador, Argentina 3: Department of Clinical Investigation, Bio Sidus SA, Buenos Aires, Argentina
Publication date: 1999-03-01
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