Provider: Ingenta Connect Database: Ingenta Connect Content: application/x-research-info-systems TY - ABST AU - International Organization for Migration Tuberculosis Working Group TI - Outcome of first-line tuberculosis treatment in migrants from Vietnam JO - The International Journal of Tuberculosis and Lung Disease PY - 1998-08-01T00:00:00/// VL - 2 IS - 8 SP - 641 EP - 646 KW - immigrants and emigrants KW - tuberculosis KW - Vietnam N2 - Setting: Screening and treatment of tuberculosis in prospective migrants from Vietnam, in the framework of the Orderly Departure Programme.

Objective: 1) To describe the outcome of first-line tuberculosis treatment, and 2) to investigate the role of prognostic factors on treatment outcome.

Design: Cohort of consecutive smear-positive patients identified by screening before departure, and followed up until cure or failure, for a maximum of two years.

Results: Seven hundred and twenty-nine patients were consecutively diagnosed with infectious tuberculosis. Patients received directly observed treatment with rifampicin, isoniazid, ethambutol and pyrazinamide for a minimum of 6 months, or until sputum conversion was maintained for 6 consecutive months. The cumulative percentage of cure with first-line treatment was 50.2% (SE = 2%) at 7 months, and 92.8% (SE = 2%) at 24 months. Young patients without cavities achieved the highest percentage of cure. Stratified testing confirmed the negative effect on the chance of cure of age >45 years (P < 0.001), and cavities (P < 0.001), while the effect of previous treatment was not significant (P = 0.105).

Conclusions: While the overall cure rate was satisfactory, older patients and those with cavities required prolonged treatment and reached a less satisfactory level of cure. UR - https://www.ingentaconnect.com/content/iuatld/ijtld/1998/00000002/00000008/art00007 ER -