Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - International Organization for Migration Tuberculosis Working Group
TI - Outcome of first-line tuberculosis treatment in migrants from Vietnam
JO - The International Journal of Tuberculosis and Lung Disease
PY - 1998-08-01T00:00:00///
VL - 2
IS - 8
SP - 641
EP - 646
KW - immigrants and emigrants
KW - tuberculosis
KW - Vietnam
N2 - Setting: Screening and treatment of tuberculosis in prospective migrants from Vietnam, in the framework of the Orderly Departure Programme.
Objective: 1) To describe the outcome of first-line tuberculosis treatment, and 2) to investigate the role of prognostic factors on treatment outcome.
Design: Cohort of consecutive smear-positive patients identified by screening before departure, and followed up until cure or failure, for a maximum of two years.
Results: Seven hundred and twenty-nine patients were consecutively diagnosed with infectious tuberculosis. Patients received directly observed treatment with rifampicin, isoniazid, ethambutol and pyrazinamide for a minimum of 6 months, or until sputum conversion was maintained for 6 consecutive months. The cumulative percentage of cure with first-line treatment was 50.2% (SE = 2%) at 7 months, and 92.8% (SE = 2%) at 24 months. Young patients without cavities achieved the highest percentage of cure. Stratified testing confirmed the negative effect on the chance of cure of age >45 years (P < 0.001), and cavities (P < 0.001), while the effect of previous treatment was not significant (P = 0.105).
Conclusions: While the overall cure rate was satisfactory, older patients and those with cavities required prolonged treatment and reached a less satisfactory level of cure.
UR - https://www.ingentaconnect.com/content/iuatld/ijtld/1998/00000002/00000008/art00007
ER -