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Free Content Outcome of first-line tuberculosis treatment in migrants from Vietnam

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Abstract:

Setting: Screening and treatment of tuberculosis in prospective migrants from Vietnam, in the framework of the Orderly Departure Programme.

Objective: 1) To describe the outcome of first-line tuberculosis treatment, and 2) to investigate the role of prognostic factors on treatment outcome.

Design: Cohort of consecutive smear-positive patients identified by screening before departure, and followed up until cure or failure, for a maximum of two years.

Results: Seven hundred and twenty-nine patients were consecutively diagnosed with infectious tuberculosis. Patients received directly observed treatment with rifampicin, isoniazid, ethambutol and pyrazinamide for a minimum of 6 months, or until sputum conversion was maintained for 6 consecutive months. The cumulative percentage of cure with first-line treatment was 50.2% (SE = 2%) at 7 months, and 92.8% (SE = 2%) at 24 months. Young patients without cavities achieved the highest percentage of cure. Stratified testing confirmed the negative effect on the chance of cure of age >45 years (P < 0.001), and cavities (P < 0.001), while the effect of previous treatment was not significant (P = 0.105).

Conclusions: While the overall cure rate was satisfactory, older patients and those with cavities required prolonged treatment and reached a less satisfactory level of cure.

Keywords: Vietnam; immigrants and emigrants; tuberculosis

Document Type: Regular Paper

Publication date: 1998-08-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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