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Free Content Epidemiology of Mycobacterium tuberculosis strains in San Francisco that do not contain IS6110

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IS6110 is commonly used as the basis for molecular epidemiologic and diagnostic studies of Mycobacterium tuberculosis. However, strains that do not contain IS6110 have been reported. If common, such strains would pose a limitation for molecular studies of M. tuberculosis. Analysis of a population-based sample from San Francisco of 1569 specimens submitted for fingerprinting demonstrated that the proportion of strains that lack IS6110 is less than 1%. While this low percentage permits IS6110 fingerprinting in San Francisco, it may be problematic in other settings.
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Keywords: IS6110; PGRS; RFLP; molecular diagnostics; molecular epidemiology; tuberculosis

Document Type: Short Communication

Affiliations: 1: Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, San Francisco, California, USA 2: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, California, USA

Publication date: 1998-06-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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