Detection of anti-lipoarabinomannan antibodies for the diagnosis of active tuberculosis
Abstract:Setting: A serological test that contributes in diagnosing tuberculosis would aid patient management.
Objective: To evaluate MycoDot™, a new commercially available serological test, for the detection of immunoglobulin G antibodies to lipoarabinomannan (LAM), a glycolipid common to mycobacteria.
Design: Serum samples from 102 non-human immunodeficiency virus (HIV)-infected patients with no previous history of tuberculosis and with suspected active pulmonary (66) and/or extra-pulmonary (36) tuberculosis were investigated; 50 HIV-negative healthy subjects, sputum culture-negative, tuberculin skin test negative and with no history of tuberculosis, were used as controls.
Results and conclusion: In 28 patients with microbiologically ascertained tuberculosis 25/28 serum samples were positive, whereas the test was negative in two patients with renal tuberculosis and in one with pulmonary tuberculosis. The remaining 74 serum samples were negative. The follow-up of these patients excluded a mycobacterial infection. Control subjects were negative. On the basis of our design, the MycoDot™ test, with its rapidity and degree of sensitivity, is suitable for routine use in laboratory diagnosis of both pulmonary and extrapulmonary tuberculosis.
Document Type: Regular Paper
Publication date: February 1, 1998
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
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