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Free Content Cycloserine-induced Stevens-Johnson syndrome in an AIDS patient with multidrug-resistant tuberculosis [Case Study]

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We report a case of cycloserine-induced Stevens-Johnson syndrome (SJS) in a 38-year-old male with the acquired immune deficiency syndrome (AIDS) and multidrug resistant tuberculosis (MDR-TB). The patient developed a cutaneous reaction after 60 days of therapy with ofloxacin, streptomycin (SM), pyrazinamide (PZA), ethambutol (EMB), and cycloserine (CSN). All drugs were stopped and the rash improved. Due to the severity of his disease, anti-tuberculosis drugs were resumed, one at a time. The patient developed a recurrent rash consistent with SJS, which began when CSN was restarted. CSN was stopped and the SJS began to gradually resolve with palliative treatment despite continuation of the other anti-tuberculosis drugs. However, the patient's overall condition gradually deteriorated and he died. To our knowledge, this is the first case of probable CSN-related SJS.
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Keywords: AIDS; Cycloserine; MDR-TB; Stevens-Johnson syndrome

Document Type: Short Communication

Affiliations: 1: Tulane University School of Medicine, New Orleans, Louisiana, USA; and Veterans Affairs Medical Center, New Orleans, Louisiana, USA 2: Veterans Affairs Medical Center, New Orleans, Louisiana, USA; and Xavier University of Louisiana College of Pharmacy, New Orleans, Louisiana, USA 3: Xavier University of Louisiana College of Pharmacy, New Orleans, Louisiana, USA

Publication date: 1997-04-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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