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Free Content Association between an early humoral response to Mycobacterium tuberculosis antigens and later development of tuberculosis in human immunodeficiency virus-infected individuals

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Objective: To evaluate the association between an early humoral response to Mycobacterium tuberculosis antigens and the later development of tuberculosis (TB) disease in human immunodeficiency virus (HIV)-infected individuals.

Methods: Using an ELISA test, IgG antibodies against 4 M. tuberculosis antigens—purified protein derivative (PPD); 2,3 diacyl trehalose (DAT); a lipooligosaccharide (LOS) and a trehalose dicarboxylic acid bis N,N-dioctadecylamide (BDA.TDA)—were measured in sera from 25 HIV-infected tuberculous patients and 52 HIV-infected persons without TB.

Results: With the DAT and LOS antigens, a positive result in sera obtained in the 12 months preceding the onset of TB was significantly associated with later development of TB. Using the BDA.TDA antigen, the same association was observed in sera collected during the 6 months before the diagnosis of TB. No significant association was found with the PPD antigen.

Conclusion: These results suggest that specific antibody markers may be useful to evaluate the risk of active TB in HIV-infected individuals, and a helpful indicator for preventive treatment.

Keywords: HIV infection; early diagnosis; serodiagnosis; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Fundação FIOCRUZ, Rio de Janeiro, RJ, Brazil 2: Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil 3: Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil 4: National Reference Centre for Tuberculosis, Ottawa, Canada

Publication date: 1997-04-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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