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Inkjet Bioprinting of Solid Peroxide Microparticles for Constructing Oxygen-Generating Scaffolds

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A major challenge in tissue engineering is to provide oxygen to cells within implanted tissues before vascularization is achieved. To overcome the limitations, oxygen generating materials have been developed to enhance cell proliferation. However, these methods provide an uneven oxygen distribution. Inkjet bioprinting technology is a novel fabrication approach, in which the bioprinter can deposit biomaterials precisely in a designed path. This technology has been applied in this study to construct oxygen-generating scaffolds. In this study we have applied the inkjet printing technology to allocate calcium peroxide (CPO) in a controlled pattern. The CPO was encapsulated with a hydrogel to provide a progressive oxygen release to cells. Oxygenized scaffolds were utilized searching for optimal cell viability in a period of 10 days under hypoxic environment. The results suggested that scaffolds containing CPO increase cell viability and proliferation in comparison to control group (no CPO) under hypoxic environment along 10 days. In consequence, the designed inkjet printing patterns provided a functional oxygen supply to scaffolds.
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Document Type: Research Article

Publication date: 2013-01-01

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  • For more than 30 years, IS&T's series of digital printing conferences have been the leading forum for discussion of advances and new directions in 2D and 3D printing technologies. A comprehensive, industry-wide conference that brings together industry and academia, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems?particularly those involved with additive manufacturing and fabrication?including bio-printing, printed electronics, page-wide, drop-on-demand, desktop and continuous ink jet, toner-based systems, and production digital printing, as well as the engineering capability, optimization, and science involved in these fields. In 2016, the conference changed its name formally to Printing for Fabrication to better reflect the content of the meeting and the evolving technology of printing.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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