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Digital Patterning of Glucose Oxidase for Electrochemical Glucose Biosensors

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Abstract:

Type 1 diabetes is a pancreatic disease that afflicts over one million people in the United States. Patients with type 1 diabetes are not able to produce their own insulin and must use portable blood glucose monitors to measure glucose levels, and have insulin delivered by injection or pump. Glucose monitoring in the subcutaneous tissue closely parallels the blood glucose values, and allows patients to be alerted to hypoglycemia and hyperglycemia conditions. We are using electrohydrodynamic (e-jet) printing to pattern glucose oxidase on flexible amperometric glucose sensors. E-jet printing is of interest for these sensors since printing of features down to 200 nm has previously been demonstrated, while e-jet printing also allows significant flexibility in the digital patterning of glucose enzyme electrodes on either rigid or flexible substrates in a variety of sizes and shapes. In this presentation we will discuss glucose oxidase ink formulation, surface pretreatment conditions, and electrochemical characterization of the printed glucose enzyme electrodes.

Document Type: Research Article

Publication date: 2013-01-01

More about this publication?
  • For more than 30 years, IS&T's series of digital printing conferences have been the leading forum for discussion of advances and new directions in 2D and 3D printing technologies. A comprehensive, industry-wide conference that brings together industry and academia, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems?particularly those involved with additive manufacturing and fabrication?including bio-printing, printed electronics, page-wide, drop-on-demand, desktop and continuous ink jet, toner-based systems, and production digital printing, as well as the engineering capability, optimization, and science involved in these fields. In 2016, the conference changed its name formally to Printing for Fabrication to better reflect the content of the meeting and the evolving technology of printing.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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