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Thermal Inkjet System to Enable Picoliter Dispense of Pharmaceutical Compounds

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A system designed to dispense small-molecule compounds dissolved in Dimethyl Sulfoxide (DMSO) into ANSI-standard wellplates has been developed by Hewlett Packard (HP). This system, based on HP's Scalable Printing Technology (SPT), includes a disposable TIJ (thermal inkjet) dispensehead cassette designed specifically for the jetting of DMSO. Each cassette uses open 7μL reservoirs that allow a researcher to load fluid directly into the dispenseheads. The system also includes an instrument that drives the dispenseheads and moves wellplates below the fixed cassette. The system finally includes software designed to specify the amount of fluid dispensed into each well, rendering complicated experiments to be simple to both design and execute.

Picoliter-dispense technology is particularly suited for the creation of direct compound titrations in well plates commonly used for dose-response experiments. Advantages over traditional serial dilution techniques include a reduction of carry over and accumulated error, an improvement in precision, and a reduction in compound usage. Additionally, the HP system enables a simpler workflow and makes finely-spaced dosages practical.

This paper describes key features of the HP system and performance data from pharmaceutical beta sites. It also describes the advantages of a TIJ-based compound-dispensing system relative to existing pipette-based or PIJ (piezo inkjet)-based systems. Finally, it describes some of the advantages of using a non-contact Digital Dispenser in this application.

Document Type: Research Article

Publication date: 2011-01-01

More about this publication?
  • For more than 25 years, NIP has been the leading forum for discussion of advances and new directions in non-impact and digital printing technologies. A comprehensive, industry-wide conference, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems, including drop-on-demand ink jet, wide format ink jet, desktop and continuous ink jet, toner-based electrophotographic printers, production digital printing systems, and thermal printing systems, as well as the engineering capability, optimization, and science involved in these fields.

    Since 2005, NIP has been held in conjunction with the Digital Fabrication Conference.

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