Three-Dimensional Formation of Magnetic Micro-Gel Beads for Tissue Engineering
Abstract:We have commenced basic research on the three-dimensional pattern formation of micro-gel beads for applications in biological tissue engineering. In this new technique, micro-gel beads are premagnetized by doping them with magnetic nanoparticles. Living cells will be included in beads for actual use. If a nonuniform magnetic field is applied to a solution containing these magnetized beads, the beads will align, contact, and form a 3D structure. The structure is controlled by the seed pattern of the magnetic particles plugged in a substrate and the profile of the magnetic field distribution. We have constructed tubes, which imitate blood vessels, for demonstration using gel beads whose diameters are of the order of several tens of micrometers. The diameter of the demonstrated tube was less than 0.5 mm and its length was 6.6 mm, although living cells were not included in the beads. Numerical calculations by using the discrete element method were conducted to confirm the formation of the tube and to predict the effect of centrifugal force, which will be applied to fill other tissues in the space between magnetically patterned beads. Although this unique technology is in the nascent stage, it can potentially be used to form threedimensional, nonuniform, and heterogeneous artificial organs for tissue engineering.
Document Type: Research Article
Publication date: January 1, 2008
For more than 25 years, NIP has been the leading forum for discussion of advances and new directions in non-impact and digital printing technologies. A comprehensive, industry-wide conference, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems, including drop-on-demand ink jet, wide format ink jet, desktop and continuous ink jet, toner-based electrophotographic printers, production digital printing systems, and thermal printing systems, as well as the engineering capability, optimization, and science involved in these fields.
Since 2005, NIP has been held in conjunction with the Digital Fabrication Conference.
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Membership Information
- Terms & Conditions
- Ingenta Connect is not responsible for the content or availability of external websites