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Engineering Challenges in Biofabrication

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Biofabrication describes the inkjet application of bioink which may include active compounds such as drugs and living cells as well as non active, scaffolding materials to build two- and three-dimensional constructs for medical treatment. Many of the challenges in tissue engineering generally and biofabrication specifically are biological in nature; however, many appear to fall within the realm of imaging and science and technology. One challenge is to arrange the donor cells into the exact patterns that will promote growth towards the desired tissue form and function. Of the many approaches that have been suggested to accurately place cells the inkjet printing approach is one of the more interesting. In these devices researchers have tailored their bioinks by two approaches, namely using new biomaterials that fit the processing window of commercial printers or developing new systems that use the biomaterials as bioink directly. Tailoring the physical properties of these inks, and developing printheads optimized for these properties will improve cell density, and the tissue fabrication speed. Biofabricated tissues can be used to build models of the effects of local environment on different cell types. The models can be incorporated into computer design and simulation environment in order to predict tissue function.
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Document Type: Research Article

Publication date: 2007-01-01

More about this publication?
  • For more than 30 years, IS&T's series of digital printing conferences have been the leading forum for discussion of advances and new directions in 2D and 3D printing technologies. A comprehensive, industry-wide conference that brings together industry and academia, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems?particularly those involved with additive manufacturing and fabrication?including bio-printing, printed electronics, page-wide, drop-on-demand, desktop and continuous ink jet, toner-based systems, and production digital printing, as well as the engineering capability, optimization, and science involved in these fields. In 2016, the conference changed its name formally to Printing for Fabrication to better reflect the content of the meeting and the evolving technology of printing.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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