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Inkjet bioprinting as an effective tool for tissue fabrication

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Recently, 3D printing and rapid prototyping techniques have been applied in tissue engineering. Many of them are used in fabricating of scaffolds of tissues, which is essential in the conservative scaffold guided tissue engineering. However, this approach using simple scaffold has some limitations to manufacture complex, large-scaled, and multi-type cells composed tissues with good reproducibility.

Then, we have ever explored the application of inkjet technique as the technologies to position and arrange such biological materials as living cells, proteins and growth factors arbitrary onto an intentionally targeted position, in three dimensions. There were several problems to be overcome, when using living cells and biological materials instead of inks. Although we have confirmed that living cells could be safely printed by inkjet with keeping living condition, cells are soon dried and dye, and printed lines are easy to mix together, and 3D structures are never constructed with cells in the liquid medium. Then, we invented inkjet hydrogel forming technique to solve such problems. Applying inkjet hydrogel forming technique, we succeeded to prevent cells from drying, and to avoid from ink mixture, and 3D structures could also be constructed. Inkjet bioprinting has many advantages and much possibility as a tool for 3D tissue engineering.

Document Type: Research Article

Publication date: January 1, 2006

More about this publication?
  • For more than 25 years, NIP has been the leading forum for discussion of advances and new directions in non-impact and digital printing technologies. A comprehensive, industry-wide conference, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems, including drop-on-demand ink jet, wide format ink jet, desktop and continuous ink jet, toner-based electrophotographic printers, production digital printing systems, and thermal printing systems, as well as the engineering capability, optimization, and science involved in these fields.

    Since 2005, NIP has been held in conjunction with the Digital Fabrication Conference.

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