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Image based printing of structured biomaterials for realizing complex 3D cardiovascular constructs

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Considerable effort has been focused on printing synthetic biodegradable scaffolds for hard tissue applications. The requirements for soft tissues, in particular cardiac tissue are somewhat unique since the cellular arrangement is more essential for achieving function. The goal of this study was to develop a technique that allows aligning of cardiomyocytes in printed channels.

A fabrication chamber was filled with a 2% alginic acid solution, a liquid that is known to crosslink under mild conditions to form a biodegradable hydrogel scaffold. An ink cartridge was filled with calcium chloride cross-linker. By printing a variety of concentrations of cross-linker, the fabrication process could be optimized by comparing the fidelity of the printed pattern to the designs.

Adult feline cardiomyocytes were added to the biomaterial and the resulting cardiac constructs were electrically stimulated. In response, the cardiac constructs contracted rhythmically and synchronously. The shortening extent of the edge was up to 7.0% of the total length of the constructs compared to 3.5 % in constructs without channels. In this study printed alginate gels demonstrated that by engineering the microstructures of the printed alginate scaffolds improved function can be achieved.
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Document Type: Research Article

Publication date: 2006-01-01

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  • For more than 30 years, IS&T's series of digital printing conferences have been the leading forum for discussion of advances and new directions in 2D and 3D printing technologies. A comprehensive, industry-wide conference that brings together industry and academia, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems?particularly those involved with additive manufacturing and fabrication?including bio-printing, printed electronics, page-wide, drop-on-demand, desktop and continuous ink jet, toner-based systems, and production digital printing, as well as the engineering capability, optimization, and science involved in these fields. In 2016, the conference changed its name formally to Printing for Fabrication to better reflect the content of the meeting and the evolving technology of printing.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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