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Drop-on Demand Printing of Cell and Materials for Designer Hybrid Cardiovascular Biomaterials

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Contractile cardiac hybrids have been fabricated by arranging alternate layers of hydrogels and mammalian cardiovascular cells according to CAD models using inkjet printers. The hybrid materials have properties that can be tailored in 3D to achieve desired porosities, mechanical and chemical properties. Alginate hydrogels with controlled microshell structures were built by spraying cross-linkers onto ungelled alginic acid using inkjet printers. Endothelial cells were seen to attach to the inside of these microshells. The cells remained viable in constructs as thick as 1 cm due to the programmed porosity. Finite element modeling was used to predict the mechanical properties and to generate CAD models with properties matching cardiac tissue. When these were printed into hybrid cardiomyocyte sheets, microscopic and macroscopic contractile function was observed. These results suggest that the printing method could be used for hierarchical design of functional cardiac patches, balanced with porosity for mass transport and structural support.
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Document Type: Research Article

Publication date: 01 January 2005

More about this publication?
  • For more than 30 years, IS&T's series of digital printing conferences have been the leading forum for discussion of advances and new directions in 2D and 3D printing technologies. A comprehensive, industry-wide conference that brings together industry and academia, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems?particularly those involved with additive manufacturing and fabrication?including bio-printing, printed electronics, page-wide, drop-on-demand, desktop and continuous ink jet, toner-based systems, and production digital printing, as well as the engineering capability, optimization, and science involved in these fields. In 2016, the conference changed its name formally to Printing for Fabrication to better reflect the content of the meeting and the evolving technology of printing.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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