Computer-Aided Tissue Engineering and Its Application for Freeform Fabrication of Tissue Substitutes

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Advances in modern design and manufacturing, biomaterials, biology and biomedicine have emerged a new field of Computer-Aided Tissue Engineering (CATE). CATE enables the application of advanced computer-aided technologies and biomechanical engineering principles to derive systematic solutions for complex tissue engineering problems. This presentation will report our recent research on CATE, including its overview and the three major application fields: 1) computer-aided tissue modeling; 2) computer-aided tissue scaffold informatics and biomimetic design, and 3) the informatics model driven digital fabrication for tissue engineering. The development of proprietary Precision Extruding Deposition (PED) process and the multi-nozzle biopolymer deposition process for freeform fabrication of tissue scaffolds and cell seeded tissue precursors will be presented. Fabrication of scaffolds by different biomaterials, including alginate, Polycaprolactone (PCL), PCL/alginate and PCL/Hydroxyapatite (HA) composites will be introduced. Results and characterizations of scaffold under different processes and the effect of the process parameters on the scaffold structural, mechanical and biological properties will also be presented.

Document Type: Research Article

Publication date: January 1, 2005

More about this publication?
  • For more than 25 years, NIP has been the leading forum for discussion of advances and new directions in non-impact and digital printing technologies. A comprehensive, industry-wide conference, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems, including drop-on-demand ink jet, wide format ink jet, desktop and continuous ink jet, toner-based electrophotographic printers, production digital printing systems, and thermal printing systems, as well as the engineering capability, optimization, and science involved in these fields.

    Since 2005, NIP has been held in conjunction with the Digital Fabrication Conference.

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