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Computer-Aided Tissue Engineering and Its Application for Freeform Fabrication of Tissue Substitutes

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Advances in modern design and manufacturing, biomaterials, biology and biomedicine have emerged a new field of Computer-Aided Tissue Engineering (CATE). CATE enables the application of advanced computer-aided technologies and biomechanical engineering principles to derive systematic solutions for complex tissue engineering problems. This presentation will report our recent research on CATE, including its overview and the three major application fields: 1) computer-aided tissue modeling; 2) computer-aided tissue scaffold informatics and biomimetic design, and 3) the informatics model driven digital fabrication for tissue engineering. The development of proprietary Precision Extruding Deposition (PED) process and the multi-nozzle biopolymer deposition process for freeform fabrication of tissue scaffolds and cell seeded tissue precursors will be presented. Fabrication of scaffolds by different biomaterials, including alginate, Polycaprolactone (PCL), PCL/alginate and PCL/Hydroxyapatite (HA) composites will be introduced. Results and characterizations of scaffold under different processes and the effect of the process parameters on the scaffold structural, mechanical and biological properties will also be presented.
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Document Type: Research Article

Publication date: 2005-01-01

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  • For more than 30 years, IS&T's series of digital printing conferences have been the leading forum for discussion of advances and new directions in 2D and 3D printing technologies. A comprehensive, industry-wide conference that brings together industry and academia, this meeting includes all aspects of the hardware, materials, software, images, and applications associated with digital printing systems?particularly those involved with additive manufacturing and fabrication?including bio-printing, printed electronics, page-wide, drop-on-demand, desktop and continuous ink jet, toner-based systems, and production digital printing, as well as the engineering capability, optimization, and science involved in these fields. In 2016, the conference changed its name formally to Printing for Fabrication to better reflect the content of the meeting and the evolving technology of printing.

    Please note: For purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

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