Skip to main content

A New Approach for the Assessment of Allergic Dermatitis Using Long Wavelength Near-Infrared Spectral Imaging

Buy Article:

$20.00 plus tax (Refund Policy)

Imaging devices for long-wavelength near-infrared light (e.g., MCT, InGaAs) and hyperspectral imaging devices using these wavelengths have recently been developed. This range of wavelengths is especially effective for measuring the composition of objects because it includes the absorption spectra of molecular vibrations. In this study, long-wavelength near-infrared spectral imaging was used to evaluate allergic dermatitis. Allergic dermatitis can be caused by 2 types of hypersensitivity, immediate (type I) and delayed (type IV), which are activated by different mechanisms. However, both types of dermatitis are characterized by erythema and localized tissue swelling of the affected area, and it is therefore difficult to determine the type of allergic response by macroscopic inspection. Near-infrared spectral imaging has attracted attention as a non-destructive inspection method, but while several studies have focused on the detection of edema by near-infrared spectroscopy, the previously reported methods have not attempted to differentiate between different types of allergic dermatitis by detecting intracutaneous targets specific to the different activation mechanisms. This study aimed to develop a method for the assessment of allergic dermatitis by using the long-wavelength near-infrared spectrum to detect intracutaneous allergic type-specific targets. Such a method was realized by establishing a spectral classifier for the spectra of type I and type IV allergic dermatitis reactions. A spectral classifier was established from the spectral datasets of histamine-induced cutaneous reaction (immediate type) and contact hypersensitivity erythema elicited by squaric acid dibutylester (SADBE; type IV), and a canonical discriminant analysis achieved very accurate detection of normal skin and types I and IV allergic dermatitis (normal skin: 87.2%, histamine induced reaction: 71.0%, SADBE contact hypersensitivity: 95.8%). The classifier was next applied to spectral images of 2 other skin conditions, red flare activated by methyl nicotinate (normal skin) and metal allergy (type IV), and these validation datasets were also correctly classified: the red flare induced by methyl nicotinate was categorized as normal skin and the contact hypersensitivity activated by the metal allergy patch test was categorized as a type IV allergic reaction. These results suggest a possible application of near-infrared spectral imaging to the assessment of allergic dermatitis.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Data/Media
No Metrics

Document Type: Research Article

Publication date: 2011-01-01

More about this publication?
  • CIC is the premier annual technical gathering for scientists, technologists, and engineers working in the areas of color science and systems, and their application to color imaging. Participants represent disciplines ranging from psychophysics, optical physics, image processing, color science to graphic arts, systems engineering, and hardware and software development. While a broad mix of professional interests is the hallmark of these conferences, the focus is color. CICs traditionally offer two days of short courses followed by three days of technical sessions that include three keynotes, an evening lecture, a vibrant interactive (poster) papers session, and workshops. An endearing symbol of the meeting is the Cactus Award, given each year to the author(s) of the best interactive paper; there are also Best Paper and Best Student Paper awards.

    Please note: for Purposes of its Digital Library content, IS&T defines Open Access as papers that will be downloadable in their entirety for free in perpetuity. Copyright restrictions on papers vary; see individual paper for details.

  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Membership Information
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more