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Free Content Lipopolysaccharide Aggravates Cerebral Pathology in B10.PL-derived CD1-/-,β2m-/-, TCRα-/-, and TCRδ-/- Knockout Mice

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Adult B10.PL-derived immunological genes knockout mice injected with 100 μg lipopolysaccharide (LPS) showed severe hydrocephalus and meningitis. A consequence of the hydrocephalus is pineal hyperplasia, sponginess of periventricular parenchyma, gliosis and, at the last stage of hydrocephalus formation, disappearance of the ependymal layer and the Gomori-positive subependymal astrocytes. Possible mechanisms for the aggravation of cerebral pathology induced by LPS are discussed.

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Keywords: HYDROCEPHALUS; KNOCKOUT MICE; LPS; MENINGITIS; PINEAL TUMORS

Document Type: Research Article

Publication date: 01 September 2006

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  • Folia biologica is an international quarterly journal that publishes papers on the broad field of experimental zoology, nuclear and chromosome research, and also ultrastructural studies. All papers are subject to peer reviews. Indexed in: ISI Master Journal List, Current Contents, Polish Scientific Journals Contents. I.F. 0.667
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