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Free Content Lipopolysaccharide Aggravates Cerebral Pathology in B10.PL-derived CD1-/-,2m-/-, TCRα-/-, and TCR-/- Knockout Mice

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Adult B10.PL-derived immunological genes knockout mice injected with 100 g lipopolysaccharide (LPS) showed severe hydrocephalus and meningitis. A consequence of the hydrocephalus is pineal hyperplasia, sponginess of periventricular parenchyma, gliosis and, at the last stage of hydrocephalus formation, disappearance of the ependymal layer and the Gomori-positive subependymal astrocytes. Possible mechanisms for the aggravation of cerebral pathology induced by LPS are discussed.


Document Type: Research Article


Publication date: 2006-09-01

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  • Folia biologica is an international quarterly journal that publishes papers on the broad field of experimental zoology, nuclear and chromosome research, and also ultrastructural studies. All papers are subject to peer reviews. Indexed in: ISI Master Journal List, Current Contents, Polish Scientific Journals Contents. I.F. 0.667
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