Genetic Aspects of Biological Processes Underlying the Defense System in the Neonate
Abstract:Preparation for postnatal life of a neonate is determined by (1) adequate pre-natal development (2) development of innate immunity and (3) transfer of maternal antibodies. In this contribution the trait "piglet survival" will be explored using quantitative methods, searching for genetic variation and for biological explanations for possible genetic differences in piglet survival. Whereas for the chicken "innate immune system defined as natural antibodies (NAbs)" will be explored using a genomic approach searching for Quantitative Trait Loci (QTL) in an F2 cross of chicken lines selected for high and low antibody responses to SRBC (Sheep Red Blood Cells). By revealing variation which underlie biological processes of neonates it is shown that the defense system of the neonate is under genetic control. Genes of the neonate influence its innate defense system, taking care of general defense and of adaptation possibilities to novel antigens. The genes of the dam help, through maternal antibodies, to survive through the early days of life. We find that the innate defense system can be improved through direct selection against mortality and that the system of natural antibodies might have single gene variation, worthy of further investigation.
Document Type: Research Article
Publication date: October 1, 2005
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- Folia biologica is an international quarterly journal that publishes papers on the broad field of experimental zoology, nuclear and chromosome research, and also ultrastructural studies. All papers are subject to peer reviews. Indexed in: ISI Master Journal List, Current Contents, Polish Scientific Journals Contents. I.F. 0.667
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