Fallibilism about knowledge and justification is a widely held view in epistemology. In this paper, I will try to arrive at a proper formulation of fallibilism. Fallibilists often hold that Cartesian skepticism is a view that deserves to be taken seriously and dealt with somehow. I argue that it turns out that a canonical form of skeptical argument depends upon the denial of fallibilism. I conclude by considering a response on behalf of the skeptic.