Quantitative analysis of wear and wear debris from metal-on-metal hip prostheses tested in a physiological hip joint simulator

Authors: Firkins P.J.¹; Tipper J.L.²; Saadatzadeh M.R.²; Ingham E.²; Stone M.H.³; Farrar R.⁴; Fisher J.⁵

Source: Bio-Medical Materials and Engineering, Volume 11, Number 2, 2001 , pp. 143-157(15)

Publisher: IOS Press

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Abstract:

Osteolysis and loosening of artificial joints caused by UHMWPE wear debris has prompted renewed interest in metal-on-metal (MOM) hip prostheses. This study investigated the wear and wear debris morphology generated by MOM prostheses in a physiological anatomical hip simulator for different carbon content cobalt chrome alloys.

The low carbon pairings demonstrated significantly higher “bedding in” and steady state wear rates than the mixed and high carbon pairings. The in vitro wear rates reported here were up to one or two orders of magnitude lower than the clinical wear rates for first-generation MOM hip prostheses. Two methods for characterising the metal wear debris were developed, involving digestion, scanning electron microscopy and transmission electron microscopy. The metal wear particles characterised by the two methods were similar in size, 25–36 nm, and comparable to particles isolated from periprosthetic tissues from first and second-generation MOM hip prostheses. Due to the small size of the metal particles, the number of particles generated per year for MOM prostheses in vitro was estimated to be up to 100 times higher than the number of polyethylene particles generated per year in vivo.

The volumetric wear rates were affected by the carbon content of the cobalt chrome alloy and the material combinations used. However, particle size and morphology was not affected by method of particle characterisation, the carbon content of the alloy or material combination.

Keywords: Hip prosthesis; wear; debris; metal-on-metal; simulation

Document Type: Research article

Affiliations: 1: Medical and Biological Engineering (MBE) Research Group, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK 2: Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK 3: Department of Orthopaedic Surgery, Leeds General Infirmary, Leeds, LS1 3EX, UK 4: Depuy International, a Johnson & Johnson company, St. Anthony's Rd, Leeds, LS11 8DT, UK 5: School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK

Publication date: 2001-01-01

Quantitative analysis of wear and wear debris from metal-on-metal hip prostheses tested in a physiological hip joint simulator

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